Protein kinase molecules and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorSusan Acton
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Abstract
The invention provides isolated nucleic acid molecules, designated CSAPK-1 nucleic acid molecules, which encode novel cardiovascular system associated protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing CSAPK-1 polypeptides.
Claims88
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1 or a complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:3 or a complement thereof.
An isolated nucleic acid molecule consisting of the nucleotide sequence set fort in SEQ ID NO:1 or a complement thereof.
An isolated nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:3 or a complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2, or a complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:2, or a complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence contained in the plasmid deposited with ATCC® as Accession Number 203308 or a complement thereof.
An isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule consisting of SEQ ID NO:1 or 3 in 6×SSC at 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C., and wherein said nucleic acid molecule encodes a polypeptide of at least 302 amino acids in length.
An isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule consisting of SEQ ID NO:1 or 3 in 6×SSC at 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C., and wherein said nucleic acid molecule encodes a polypeptide of at least 302 amino acids in length.
An isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least about 98% identical to the amino acid sequence of SEQ ID NO:2, wherein said nucleic acid molecule encodes a polyfeptide of at least 302 amino acids in length.
An isolated nucleic acid molecule which encodes a polypeptide consisting of an amino acid sequence at least about 98% identical to the amino acid sequence of SEQ ID NO:2, wherein said nucleic acid molecule encodes a polypeptide of at least 302 amino acids in length.
Dependencies are inferred from the claim text.