Method for evaluating the metastatic tendency of tumors
AssigneeHadasit Medical Research Services and Development Ltd.
InventorRachel Bar-Shavit
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Abstract
The present invention concerns a method for evaluating the metastatic tendency of tumor cells by determining the level of expression (mRNA level) of the gene coding for the thrombin receptor (ThR) or by determining the level of the thrombin receptor present on the membranes or within the tumor cells. A high level of either of the above indicates a high metastatic tendency, a low level indicates a low metastatic tendency and an intermediate level indicates a moderate metastatic tendency. The present invention further concerns a kit for use in the above method.
Claims4
A method for determining whether the metastatic tendency of tumor cells is high or low, said method comprising:
- (a) (quantitating the level of thrombin receptor (ThR) mRNA in said tumor cells;
- and
- (b) comparing said level with a control level, said control level being a level of ThR mRNA from a cell known to have a high metastatic tendency or a cell known to have a low metastatic tendency, a high or low level of the ThR mRNA in the tumor cells as determined by said comparison indicating a high or low metastatic tendency of the tumor cells, respectively.
Dependencies are inferred from the claim text.