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AssigneeDuphar International Research B.V.
InventorsPaulus M. Van Balken, Jules A. C. Elbers, Henderik W. Frijlink, Wienman E. Philips
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The invention relates to an Oral Delayed Immediate Release formulation comprising a compressed core containing one or more active substances surrounded with a coating, wherein release of active substance from the core is caused by rupture of the coating after a definite lag-time, said core comprising one or more immediate release carriers and having no substantial swelling properties upon exposure to gastrointestinal fluids. The invention further relates to formulations containing an Immediate Release formulation combined with one or more Oral Delayed Immediate Release formulations with different lag-times and to a method of preparing an Oral Delayed Immediate Release formulation. The Oral Delayed Immediate Release formulation may be used for the application of active substances whenever a certain lag-time before release is advantageous, such as in be the case of anti-asthmatics, anti-emetics, cardiotonics, vasodilators, anti-vertigo and anti-meniere compounds, anti-hypertensives, sedatives, anti-depressants, anti-anxiety compounds, cortico-steroids, general anti-inflammatory compounds, anti-inflammatory compounds for gastrointestinal use, anti-ulceratives, analgetics, anti-aritmics, anti-rheumatics, anti-arthritic compounds and anti-angina compounds. The Oral Delayed Immediate Release formulation may also be used for the application of biological active compounds such as proteins, peptides, enzymes, vaccines and oligonucleotides.
An Oral Delayed Immediate Release formulation comprising a compressed substantially non-swellable core containing one or more active substances surrounded with a coating, wherein release of active substance from the core is caused by rupture of the coating upon exposure to gastrointestinal fluids after a definite delay from said exposure, said core comprising one or more immediate release carriers and said core having no substantial swelling properties upon exposure to gastrointestinal fluids.
An Oral Delayed Immediate Release formulation comprising a compressed substantially non-swellable core containing one or more active substances surrounded with a coating containing one or more polymeric coating materials, wherein release of active substance(s) from the core is caused by rupture of the coating upon exposure to gastrointestinal fluids after a definite delay from said exposure, said core comprising one or more immediate release carriers and said core having no substantial swelling properties upon exposure to gastrointestinal fluids, and said polymeric coating materials being essentially non-soluble and/or non-erodable in gastrointestinal fluids.
Dependencies are inferred from the claim text.