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AssigneeCollaborative Laboratories, Inc.
InventorsDuncan T. Aust, Michael A. Ross, James M. Wilmott, James A. Hayward
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The present invention provides for vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof incorporated into liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver vitamin A derivative materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The encapsulated vitamin A derivative is thus stabilized by the liposomes. The present invention thus also provides a method of stabilizing vitamin A derivative be encapsulation in such liposomes. The liposomes of the invention are used to provide topical skin treatment formulations useful in the treatment of skin.
A liposome composition comprising alkylammonium fatty acid salts and a vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof, wherein said liposome composition is substantive to epithelial cells and skin, said liposome formed by a process comprising the steps of:
A topical skin treatment formulation comprising a vitamin A derivative selected from the group consisting of retinol, retinyl ester or any combination thereof, said vitamin A derivative being encapsulated by a liposome, wherein said liposome comprises alkylammonium fatty acids salts and wherein said liposome is substantive to epithelial cells and skin, said encapsulation formed by a process comprising the steps of:
A method for the dermatological treatment of a skin condition, comprising applying a topical cosmetic skin formulation comprising a vitamin A derivative selected from the group consisting of retinol, retinyl ester or any combination thereof, said vitamin A derivative being encapsulated by a liposome, wherein said liposome comprises alkylammonium fatty acids salts and wherein said liposome is substantive to epithelial cells and skin, comprising the steps of:
A method of stabilizing a vitamin A derivative comprising encapsulating said derivative in a liposome, wherein said liposome comprises alkylammonium fatty acids salts, said encapsulation formed by a process comprising the steps of:
Dependencies are inferred from the claim text.