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US 6,183,768 B2Granted
Implantable medicine releasing corpuscles and method of making, implanting and removing the same
OwnerAnton Härleinventor
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OwnerAnton Härleinventor
Estimating the term…
Corpuscles for implantation into or at body tissue have carriers of biologically inert material, and such carriers contain medicine which is distributed therein for release into body tissue upon completion of the implanting operation. The configuration of the carriers departs from a spherical or an exact spheroidal shape. The end sections of the carriers can have conical, frustoconical, semiellipsoidal, or semispherical shapes and can consist of pairs of identical or different segments. The central sections of the carriers can resemble barrels, or their central longitudinal cross sections can have conical, elliptical, straight or other outlines. The carriers have central or substantially central longitudinal passages for a filament which supports a surgically implantable composition constituting a row or file or string of two or more identical and/or different carriers. The transverse cross sections of the carriers can have circular, elliptical, polygonal and/or other outlines. An advantage of the corpuscles is that the surface-to-volume ratio of their carriers is more satisfactory than that of the carriers forming part of conventional corpuscles so that they can be readily withdrawn from the body.
A surgically implantable and removable composition of a plurality of corpuscles strung together by a filament, each of said corpuscles comprising a carrier of biologically inert material and a medicine for localized treatment of body tissue diseases, said medicine being releasably confined in and being distributed in said inert material and said carriers having elongated passages for the filament and each said passage having first and second open ends, said carriers further having configurations other than an exact spheroid configuration to facilitate removal of the implanted composition and external surfaces including tapering first and second portions at said first and second open ends, respectively, to further facilitate removal of the implanted composition, at least one of said first and second portions having, at least in part, an arcuate outline in at least one transverse plane crossing the respective passage.
A method of making and utilizing a composition of a plurality of corpuscles each of which comprises a carrier consisting at least in part of a biologically inert material and having an external surface, and a medicine selected for localized treatment of body tissue diseases and being releasably confined and distributed in the material of the carrier, comprising the steps of:
Dependencies are inferred from the claim text.