Avipox virus containing DNA sequences encoding herpesvirus glycoproteins
AssigneeHealth Research, Inc.
InventorEnzo Paoletti
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Abstract
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from herpesvirus. In one embodiment, the foreign DNA is expressed in a host by the production of a herpesvirus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two, particularly two or three, herpesvirus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, the barrier of maternal immunity in a newborn offspring can be overcome or avoided.
Claims23
A recombinant avipox virus containing therein DNA from herpesvirus in a nonessential region of the avipox virus genome;
- wherein said DNA codes for a herpesvirus glycoprotein.
A recombinant avipox virus containing therein exogenous DNA and a promoter operably linked to said DNA for expressing said DNA;
- wherein said promoter is superimposed on the initiation codon of said DNA.
A recombinant avipox virus containing therein DNA from equine herpesvirus in a nonessential region of the avipox virus genome;
- wherein said DNA codes for an equine herpesvirus glycoprotein.
A recombinant avipox virus containing therein DNA from herpesvirus and a promoter operably linked to said DNA for expressing said DNA;
- wherein said DNA codes for a herpesvirus glycoprotein.
An immunological composition comprising a carrier and a recombinant avipox virus as claimed in any one of claims 1, 2, 3, 5, 6, 16, 17, 12 or 14.
Dependencies are inferred from the claim text.