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US 6,183,711 B2Granted
Apatite-forming-systems: methods and products
AssigneeTetsuo Nakamoto
InventorsTetsuo Nakamoto, William B. Simmons, Jr., Alexander U. Falster
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Abstract
Methods comprise contacting apatite-forming-systems with partially alkylated xanthines. The methods include pharmaceutical applications of partially alkylated xanthines to mitigate the effects of hard tissue diseases. Products comprise apatite formed from apatite-forming-systems contacted with partially alkylated xanthines.
Claims8
A method for increasing crystallite size of an apatite, thereby decreasing the angular range of x-rays diffracted therefrom, comprising the steps of:
- providing a partially alkylated xanthine chosen from the group consisting of compounds of the formula:
- wherein a hydrogen comprises one of the R1, R2, and R3 substituents, and alkyl groups independently comprise two of the substituents;
- and
- contacting an apatite-forming-system with an amount of the partially alkylated xanthine sufficient to increase the crystallite size of the apatite formed therefrom;
- and
- maintaining an ambient temperature of about 15 to 45° C. for a period sufficient to crystallize apatite, and
- wherein the apatite forming system comprises a solution of CaCl2 and Na3PO4 at a pH of approximately 9-9.5.
4 more elements
Dependencies are inferred from the claim text.