US 6,181,414 B2 · Infrared spectroscopy for medical imaging

Abstract

A multi-channel spectral imaging module for an automated testing system for cytological applications. The multi-channel spetral imaging module generates four channels of digitized images of a cytological specimen for further processing in the automated testing system. The multi-spectral imaging module comprises a visible light source and an infrared light source, an optical imaging module, a prism module, and an output stage. The cytological specimen is strobed by the visible light and infrared light sources and the illuminated images of the specimen are focussed and coupled to the prism module by the optical imaging module. The prism module breaks the illuminated image into four channels comprising three visible light channels and an infrared channel. The output stage comprises a CCD array sensor for each channel. The CCD array sensor digitizes the image for channel and produces an output for further processing. The digitized output from the infrared channel provides additional information which is used by the automated testing system. The additional information derived from the infrared channel includes segmentation information, new identifying features for the specimen, and discrimination measures independent of the visible light channels. In another embodiment, a fifth channel is provided for a reference infrared output and the two infrared channels are operated in a differential mode.

Claims12

Dependent claims

A multi-channel spectral imaging module for an automated testing system for cytological application, said multi-channel spectral imaging module comprising:

(a) a light source module for illuminating a cytological specimen, said light source including a visible light source and an infrared light source and a control input for actuating said visible and infrared light sources;
(b) an optical imaging module for receiving illuminated images of said cytological specimen and including a lens system for focussing said illuminated images;
(c) a prism module for receiving said illuminated images from said optical imaging module, said prism module including three prism elements for producing three respective image channels in the visible spectrum and a fourth prism element for producing an image channel in the infrared spectrum, and said prism module further including a charge coupled device for each of said channels for converting the respective image into an electrical signal.

A method for generating multi-spectral image data for a cytological specimen, said method comprising the steps of:

(a) exposing said cytological specimen to a burst of broad-band light to produce a broad-band light image;
(b) separating said broad-band light image into a plurality of spectral bands;
(c) simultaneously capturing an image for each of said spectral bands and generating electrical signals corresponding to each of said captured spectral images;
(d) converting the electrical signals corresponding to said captured spectral images into a data form suitable for further processing by an automated testing system;
(e) exposing said cytological specimen to a burst of infrared light to produce an infrared light image;
(f) separating said infrared light image into a plurality of infrared spectral bands;
(g) simultaneously capturing an image for each of said infrared spectral bands and generating electrical signals corresponding to each of said captured infrared spectral images;
(h) converting the electrical signals corresponding to said captured infrared spectral images into a data form suitable for further processing by an automated testing system.

5 more elements

Dependencies are inferred from the claim text.

Infrared spectroscopy for medical imaging

Life of this patent

Infrared spectroscopy for medical imaging

Life of this patent

Abstract

Claims12