Method for treatment of dermatological disorders
AssigneeTamarkin Pharmaceutical Innovation Ltd.
InventorDov Tamarkin
Life of this patent
Estimating the term…
Abstract
A compound effect for the treatment of dermatological disorders comprises a mono- or diester of an α,ω-dicarboxylic acid, wherein the alcohol moiety of the said ester comprises a keratolytically active alcohol. The compound may have the formula, where n is in the range of 6 to 12; m is in the range of 0 to 8; R′ is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl, OH, NHR″, CONHR″ and COOR″; R″ is selected from the group consisting of alkyl, aryl, alkenyl, and benzyl; and Y is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl and X.
Claims48
A method of treating dermatological disorders, comprising:
- administering topically, nasally, orally or parenterally to a subject having said dermatological disorder a therapeutically effective amount of a compound comprising a mono- or diester of an α,ω-dicarboxylic acid, wherein at least one ester moiety of the said compound comprises a keratolytically active alcohol.
A method of increasing penetration of an α,ω-dicarboxylic acid across the skin, comprising:
- applying a mono or diester of the α,ω-dicarboxylic acid to the skin, said ester moiety comprises a keratolytically active alcohol moiety.
A method of increasing penetration of a salicylic acid across the skin, comprising:
- applying a mono or disalicylate ester derivative of the α,ω-dicarboxylic acid to the skin.
A compound, comprising:
- an α,ω-dicarboxylic acid covalently linked through an ester bond with at least one keratolytically active alcohol moiety, having the formula,
- where n is in the range of 6 to 12;
- m is in the range of 0 to 8;
- R′ is selected from the group consisting of aryl, alkenyl, benzyl, OH, NHR″, CONHR″ and COOR″;
- R″ is selected from the group consisting of alkyl, aryl, alkenyl, and benzyl;
- and Y is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl and X.
A pharmaceutical or cosmetic composition, comprising:
- a therapeutically effective amount of a compound comprising a mono- or diester of an α,ω-dicarboxylic acid, wherein the ester comprises a keratolytically active alcohol moiety, and having the formula
- where n is in the range of 6 to 12;
- m is in the range of 0 to 8;
- R′ is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl, OH, NHR″, CONHR″ and COOR″;
- R″ is selected from the group consisting of alkyl, aryl, alkenyl, and benzyl;
- and Y is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl and X;
- and
- a pharmaceutically or cosmetically acceptable carrier.
A pharmaceutical or cosmetic composition comprising:
- a therapeutically effective amount of a compound comprising a mono- or diester of an α,ω-dicarboxylic acid with a keratolytically active alcohol, wherein the keratoyltically active alcohol comprises an α-hydroxy acid or derivatives thereof;
- and
- a pharmaceutically or cosmetically acceptable carrier.
A pharmaceutical or cosmetic composition comprising:
- a therapeutically effective amount of a compound comprising a mono- or diester of an α,ω-dicarboxylic acid of a keratolytically active alcohol, wherein the keratolytically active alcohol comprises a retinol moiety or derivatives thereof;
- and
- a pharmaceutically or cosmetically acceptable carrier.
Dependencies are inferred from the claim text.