Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
AssigneeGenSci OrthoBiologics, Inc.
InventorsCharles C. Chen, Steven R. Jefferies
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Abstract
Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors, drugs, calcium-containing compounds, blood products, large molecular weight proteins, or combinations thereof. These materials can be used in a wide range of clinical procedures to replace and restore osseous or periodontal defects.
Claims56
An osteogenic composition having enhanced osteogenic potential, the composition comprising
- a porous or semi-porous matrix;
- at least one osteoinductive factor;
- and,
- at least one growth factor, nutrient factor, drug, calcium-containing compound, anti-inflammatory agent, antimicrobial agent, blood product, large molecular weight protein, or combination thereof present on or within the porous or semi-porous matrix or present on or within the osteoinductive factor.
An osteogenic composition having enhanced osteogenic potential, the composition comprising
- a porous or semi-porous matrix of collagen;
- at least one osteoinductive factor which is demineralized bone particles, Bone Morphogenetic Protein-2 (BMP-2), Bone Morphogenetic Protein-7 (BMP-7) or a combination thereof;
- and,
- at least one growth factor wherein the growth factor is present on or within the matrix and/or is present on or within the osteoinductive factor.
An osteogenic composition having enhanced osteogenic potential, the composition comprising
- a porous or semi-porous matrix of collagen;
- at least one osteoinductive factor;
- and,
- a Transforming Growth Factor-Beta (TGF-β) present on or within the matrix or on or within the osteoinductive factor.
An improved osteogenic composition having enhanced osteogenic potential, the composition comprising:
- a bone graft material of about 65 to about 95 weight percent of a porous or semi-porous matrix of reconstituted collagen;
- and about 35 to about 5 weight percent of an osteoinductive factor which is demineralized bone particles, solubilized bone morphogenetic protein, or mixtures of demineralized bone particles and solubilized bone morphogenetic protein;
- wherein the improvement comprises,
- at least one growth factor, nutrient factor, drug, calcium-containing compound, anti-inflammatory agent, blood product, calcium-containing compound, large molecular weight protein, or combination thereof is added to the composition.
Dependencies are inferred from the claim text.