Attenuated hepatitis a virus vaccine which grows in MRC-5 cells
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsAnn W. Funkhouser, Suzanne U. Emerson, Robert H. Purcell, Eric D'Hondt
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Abstract
A live hepatitis A virus (HAV) adapted to grow in MRC-5 cells is described, the HAV preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation. Methods for adapting HAV to grow in MRC-5 cells, vaccine compositions comprising the attenuated HAV, and methods of vaccinating humans against HAV infection are also described.
Claims6
A hepatitis A virus HAV 4380 having Institute Pasteur Accession No. I-936, where said virus is characterized by the ability to grow in MRC-5 cells.
A hepatitis A virus encoded by a nucleic acid molecule having the nucleic acid sequence according to SEQ ID NO:3.
Dependencies are inferred from the claim text.