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AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsEugene A. Woltering, Gregory D. Espenan
Estimating the term…
Administration of a radioisotopic compound by infusion over a period of time greater than two hours, preferably greater than twelve hours, greatly increases the maximum radioactivity that accumulates in the target cell. The efficacy of the administration of the radiolabeled compound can be increased about five times higher than prior bolus injection or short infusion methods. This method enhances the tumor to background ratio by increasing the actual radioligand accumulated inside the target cells. This technique works for any radiolabeled compound whose cellular uptake is limited by a cellular process of either binding to a cellular receptor or to a transport protein. Once the radiolabeled compound is bound and internalized, the ability of an unlabeled compound to compete with the radioligand is markedly decreased. The primary factor governing residence time after internalization is the physical half-life of the radioisotope, not biologic half-life.
A method for selectively accumulating a receptor-dependent radiolabeled compound inside target cells in a patient, wherein the target cells are selected from the group consisting of tumor cells and angiogenic cells, wherein the target cells express receptors for the radiolabeled compound, comprising administering a dose of the radiolabeled compound to the patient by infusion during a period greater than two hours, wherein the resulting residence time of the radiolabeled compound in the target cells is at least one and one-half (1.5) times the residence time of the radiolabeled compound in the target cells that would result from a bolus administration of the same total dose of the same radiolabeled compound to the patient.
Dependencies are inferred from the claim text.