Preparation of acid amides and metallization of compounds
AssigneeDeutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsHannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. This invention also concerns a process for metalating compounds which can be bonded to a metal ion by reacting the compound with a metal ion in molten urea. Furthermore, the invention deals with the thus obtained products and their use for the therapy and/or diagnosis of tumors or inflammatory diseases.
Claims28
A process for preparing an acid amide, comprising reacting an acid with an aliphatic amine in molten urea.
A process for metalating a compound which can be bonded to a metal ion, comprising reacting the compound with a metal ion in molten urea.
A process for preparing an acid amide comprising reacting an acid with an aliphatic amine in molten urea, wherein:
- (a) the acid is selected from the group consisting of carboxylic, sulfonic and phosphonic acid and wherein the aliphatic amine acid is selected from the group consisting of diethylenetriamine pentaacetic acid, diethylenetriamine pentamethylene phosphonic acid, an acid group-containing porphyrine, an acid group-containing phthalocyanine, an acid group-containing naphthalocyanine, an acid group-containing chlorin, an acid group-containing bacteriochlorine, an acid group-containing chlorophyll, an acid group-containing bacteriochlorophyll and derivatives thereof;
- and
- (b) wherein the reaction temperature is from about 120 to about 170° C.
A method for preparing a metallized acid amide comprising one or more steps selected from the group consisting of:
- (a) reacting an acid with an aliphatic amine in molten urea to provide an acid amide;
- (b) reacting an acid amide with a metal ion in molten urea;
- and
- (c) reacting an acid with a metal ion in molten urea.
A method for simultaneous metallization and acid amide formation comprising reacting an acid, an aliphatic amine, and a metal ion in molten urea.
Dependencies are inferred from the claim text.