Methods to increase blood flow to ischemic tissue
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere DiZerega
Life of this patent
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Abstract
The present invention provides methods and kits for increasing blood flow to ischemic tissue, comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
Claims8
A method for increasing blood flow to ischemic cardiac tissue comprising the administration of an amount effective for increasing blood flow to ischemic cardiac tissue of at least one active agent comprising a sequence selected from the group consisting of angiotensinogen, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, and SEQ ID NO:42.
A kit for increasing blood flow to ischemic cardiac tissue, comprising:
- (a) an amount effective for increasing blood flow to ischemic cardiac tissue of at least one active agent comprising a sequence selected from the group consisting of angiotensinogen, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, and SEQ ID NO:42 and;
- (b) instructions for using the amount effective of active agent for increasing blood flow to ischemic cardiac tissue.
A method for increasing blood flow to ischemic cardiac tissue comprising the administration of an amount effective for increasing blood flow to ischemic cardiac tissue of at least one active agent comprising a sequence selected from the general formula:
- R1-Arg-R2-R3-R4-His-Pro-R5,
- wherein
- R1 is Asp or is absent;
- R2 is selected from the group consisting of Val, Ala, Ile, Pro, Lys, Norleu, and Leu;
- R3 is selected from the group consisting of Ala, Tyr, and Tyr(PO3)2;
- R4 is selected from the group consisting of Val, Ala, Ile, Norleu, and Leu;
- R5 is Phe, Ile, or is absent;
- and
- wherein the active agent is not AII.
A kit for increasing blood flow to ischemic cardiac tissue, comprising:
- (a) an amount effective for increasing blood flow to ischemic cardiac tissue of at least one active agent comprising a sequence selected from the general formula
- R1-Arg-R2-R3-R4-His-Pro-R5,
- wherein
- R1 is Asp or is absent;
- R2 is selected from the group consisting of Val, Ala, Ile, Pro, Lys, Norleu, and Leu;
- R3 is selected from the group consisting of Ala, Tyr, and Tyr(PO3)2;
- R4 is selected from the group consisting of Val, Ala, Ile, Norleu, and Leu;
- R5 is Phe, Ile, or is absent;
- wherein the active agent is not AII;
- and
- (b) instructions for using the amount effective of active agent for increasing blood flow to ischemic cardiac tissue.
Dependencies are inferred from the claim text.