Compositions and methods for treatment of hepatitis C virus-associated diseases
AssigneeIsis Pharmaceuticals, Inc.
InventorsKevin P. Anderson, Ronnie C. Hanecak, Chikateru Nozaki
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Abstract
Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.
Claims11
An antisense oligonucleotide up to 50 nucleotides in length which comprises at least a 5-nucleotide portion of SEQ ID NO:6 and which inhibits the function of HCV genomic or messenger RNA.
An antisense oligonucleotide comprising SEQ ID NO:6.
A phosphorothioate oligodeoxynucleotide comprising SEQ ID NO:6 wherein every cytidine nucleotide is a 5′-methylcytidine.
Dependencies are inferred from the claim text.