Methods of identifying lung homing molecules using membrane dipeptidase
AssigneeThe Burnham Institute
InventorsDaniel Rajotte, Renata Pasqualini, Erkki Ruoslahti
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Abstract
The present invention provides a method of identifying a membrane dipeptidase (MDP)-binding homing molecule that selectively homes to lung endothelium. The method includes the steps of contacting MDP with one or more molecules; and determining specific binding of a molecule to the MDP, where the presence of specific binding identifies the molecule as a MDP-binding homing molecule that selectively homes to lung endothelium. Such MDP-binding homing molecules can be linked to a moiety and, when administered to a subject as a conjugate, can selectively direct the moiety to lung endothelium in the subject.
Claims5
A method of identifying a MDP-binding homing molecule that selectively homes to lung endothelium, comprising:
- (a) contacting membrane dipeptidase (MDP) with one or more molecules;
- and
- (b) detecting specific binding of at least one of said molecules to said MDP,
- wherein the presence of specific binding identifies said molecule as a MDP-binding homing molecule that selectively homes to lung endothelium.
Method of identifying a MDP-binding homing molecule that selectively homes to lung endothelium, comprising:
- (a) contacting membrane dipeptidase (MDP) with one or more molecules;
- and
- (b) determining selective inhibition of MDP by at least one of said molecules,
- wherein the presence of selective inhibition identifies said molecule as a homing molecule that selectively homes to lung endothelium.
Dependencies are inferred from the claim text.