Transdermal pressure sensitive adhesive drug delivery system
AssigneeAdhesives Research, Inc.
InventorsDonald J. Therriault, Michael J. Zajaczkowski, Barbara A. Stutzman
Life of this patent
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Abstract
A transdermal drug delivery system is provided which includes an optionally crosslinked macromer-reinforced (meth)acrylic ester base copolymer pressure sensitive adhesive wherein the macromer includes repeat hydrophilic units.
Claims116
A pressure sensitive adhesive drug delivery composition for use in the transdermal administration of a pharmacologically active agent comprised of a homogeneous admixture of a hydrophilic macromer reinforced copolymer and a pharmacologically active agent, said copolymer comprising the crosslinked reaction product of:
- (1) at least one A monomer consisting of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol, said alcohol having from 1 to 30 carbon atoms, wherein at least about 30 percent by weight of said A monomer consists of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol having at least 12 carbon atoms, and said at least one A monomer exhibiting an average number of carbon atoms in the alcohol portion of the total (meth)acrylic acid esters of at least 10,
- (2) optionally at least one B monomer,
- (3) optionally a polymeric graft moiety C having a Tg greater than 20° C., and
- (4) a graft macromer D containing hydrophilic repeat units.
A transdermal delivery system for administering a pharmacologically active agent comprising a flexible backing material impermeable to said active agent and a pressure sensitive adhesive layer on at least a portion of said backing material for adhesion of said transdermal delivery system to the skin, said pressure sensitive adhesive being in homogeneous admixture with said active agent, said pressure sensitive adhesive comprising a crosslinked graft macromer reinforced copolymer formed by the reaction of:
- (1) at least one A monomer consisting of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol, said alcohol having from 1 to 30 carbon atoms, wherein at least about 30 percent by weight of said A monomer consists of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol having at least 12 carbon atoms, and said at least one A monomer exhibiting an average number of carbon atoms in the alcohol portion of the total (meth)acrylic acid esters of at least 10,
- (2) optionally at least one B monomer,
- (3) optionally a polymeric graft moiety C having a Tg greater than 20° C., and
- (4) a graft macromer D containing hydrophilic repeat units.
In a transdermal delivery system for administering a pharmacologically active agent comprising a flexible backing material and a pressure sensitive adhesive layer for adhesion of said transdermal delivery system to the skin, said pharmacologically active agent being contained within either a reservoir attached to said backing material or within a matrix layer between said backing material and said pressure sensitive adhesive layer, the improvement wherein said pressure sensitive adhesive comprises an optionally crosslinked graft macromer reinforced copolymer formed by the reaction of:
- (1) at least one A monomer consisting of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol, said alcohol having from 1 to 30 carbon atoms, wherein at least about 30 percent by weight of said A monomer consists of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol having at least 12 carbon atoms, and said at least one A monomer exhibiting an average number of carbon atoms in the alcohol portion of the total (meth)acrylic acid esters of at least 10,
- (2) optionally at least one B monomer,
- (3) optionally a polymeric graft moiety C having a Tg greater than 20° C., and
- (4) a graft macromer D containing hydrophilic repeat units.
A pressure sensitive adhesive composition for use in the transdermal administration of a pharmacologically active agent comprised of an admixture of a hydrophilic macromer reinforced copolymer, a percutaneous penetration enhancer and a pharmacologically active agent, said copolymer comprising the reaction product of:
- (1) at least one A monomer consisting of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol, said alcohol having from 1 to 30 carbon atoms, wherein at least about 30 percent by weight of said A monomer consists of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol having at least 12 carbon atoms, and said at least one A monomer exhibiting an average number of carbon atoms in the alcohol portion of the total (meth)acrylic acid esters of at least 10,
- (2) optionally at least one B monomer,
- (3) optionally a polymeric graft moiety C having a Tg greater than 20° C., and
- (4) a graft macromer D containing hydrophilic repeat units.
A transdermal delivery system for administering a pharmacologically active agent comprising a flexible backing material impermeable to said active agent and a pressure sensitive adhesive layer on at least a portion of said backing layer in admixture with a percutaneous penetration enhancer and a pharmacologically active agent, said pressure sensitive adhesive comprising a graft macromer reinforced copolymer formed by the reaction of:
- (1) at least one A monomer consisting of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol, said alcohol having from 1 to 30 carbon atoms, wherein at least about 30 percent by weight of said A monomer consists of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol having at least 12 carbon atoms, and said at least one A monomer exhibiting an average number of carbon atoms in the alcohol portion of the total (meth)acrylic acid esters of at least 10,
- (2) optionally at least one B monomer,
- (3) optionally a polymeric graft moiety C having a Tg greater than 20° C., and
- (4) a graft macromer D containing hydrophilic repeat units.
Dependencies are inferred from the claim text.