Synthetic peptides and vaccines comprising same
AssigneesCounsel of the Queensland Institute of Medical Research, Commonwealth Scientific and Industrial Research Organisation, The University of Melbourne, Walter and Eliza Hall Institute of Medical Research of Royal Melbourne Hospital, Biotech Australia PTY Limited, CSL Limited
InventorsJuan Anton Cooper, Wendy Anne Relf, Michael Francis Good, Allan James Saul
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Abstract
The present invention relates generally to chimeric peptides comprising one or more protective epitopes in a conformation enabling inmunological interactivity and to vaccine compositions comprising same. The present invention is particularly directed to a chimeric peptide capable of inducing protecting antibodies against Group A streptococci.
Claims11
A chimeric peptide comprising:
- (i) a first amino acid sequence which, in its native state, presents a conformational epitope, said conformational epitope not being present in the first amino acid sequence in an isolated state;
- and
- (ii) a second amino acid sequence which has a conformation similar to the native conformation of the first amino acid sequence;
- wherein the first amino acid sequence is inserted within the second amino acid sequence such that the first amino acid sequence presents the conformational epitope.
Dependencies are inferred from the claim text.