Escape mutant of the surface antigen of hepatitis B virus
AssigneeDiaSorin International Inc.
InventorsDaniele Primi, Gianfranco Fiordalisi, Mario Palla
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Abstract
The invention provides an isolated mutant hepatitis B surface antigen protein which comprises an amino acid sequence of a surface antigen protein of hepatitis B virus which infects humans, in which the amino acid at position 121 is not cysteine and. at least one of the amino acids at positions 120, 122, 123, 147, or 149 is not a conserved amino acid for its position. The invention also provides a method for detecting in a sample a mutant hepatitis B surface antigen protein or a particle containing the protein.
Claims34
An isolated mutant hepatitis B surface antigen protein which comprises an amino acid sequence of a surface antigen protein of hepatitis B virus which infects humans, in which the amino acid at position 121 is not cysteine and at least one of the amino acids, at positions 120, 122, 123, 147, or 149 is not a conserved amino acid for its position.
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