Hydrazide compounds

A compound selected from those of formula (I):

• R—NH—A—CO—NH—NH—(W)n—Z (I)
• wherein:
• n is 0 or 1,
• W represents —CO— or S(O)r wherein r is 0, 1 or 2,
• Z represents a group selected from optionally substituted aryl and optionally substituted arylalkyl,
• R represents a group selected from:
• Z1—T—CO—
• Z1—O—T—CO—
• Z1—T—O—CO—
• Z1—T—S(O)q—
• wherein:
• Z1 represents optionally substituted aryl or optionally substituted arylalkyl,
• T represents a σ bond, alkylene, alkenylene, or alkynylene,
• q represents an 0, 1 or 2,
• A represents alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene,
• wherein B1 represents optionally substituted aryl or optionally substituted arylalkyl, with the proviso that when simultaneously n is 0, A represents
• B1 being benzyl, and Z represents optionally substituted phenyl, then R is other than benzoyl, its enantiomers, diastereoisomers, and pharmaceutically-acceptable an addition salts thereof with an pharmaceutically-acid or base, it being understood that:
• the term “alkyl” denotes a linear or branched alkyl group having 1 to 6 carbon atoms,
• the term “alkylene” denotes a linear or branched bivalent alkylene radical containing from 1 to 6 carbon atoms, unless indicated otherwise,
• the term “alkenylene” denotes a linear or branched bivalent alkylene radical containing 2 to 6 carbon atoms and 1 to 3 double bonds, unless indicated otherwise,
• the term “alkynylene” denotes a linear or branched alkylene bivalent radical containing 2 to 6 carbon atoms and 1 to 3 triple bonds, unless indicated otherwise,
• the term “aryl” denotes phenyl, naphthyl, dihydronaphthyl or tetrahydronaphthyl, and the term “arylene” denotes a bivalent radical of the same type,
• the term “alkylenecycloalkylene” represents —A1—A2—, the term “cycloalkylene-alkylene” represents —A2—A1—, and the term “alkylenecycloalllylenealkylene” represents —A1—A2—A1, the term “alkylenearylene” represents —A1—A3—, the term “arylenealkylene” represents —A3—A1—, the term “alkylenearylenealkylene” represents —A1—A3—A1—, wherein A1 is alkylene as defined hereinbefore, A2 is (C4-C8)cycloalkylene, and A3 is arylene as defined hereinbefore,
• the expression “optionally substituted” applied to the terms “aryl” or, “arylalkyl”, indicates that those groups maybe substituted on their cyclic moiety by 1 to 5 identical or different substituents selected from linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, halogen, hydroxy, perhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, nitro, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkylsulphonyl, and amino (amino being optionally substituted by one or two linear or branched (C1-C6)alkyl and/or linear or branched (C1-C6)acyl).