Yellow fever infectious cDNA and plasmids
AssigneeFundaco Oswaldo Cruz-Fiocruz
InventorsRicardo Galler, Marcos Da Silva Freire
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Abstract
The present invention is related to a vaccine composition for humans against YF infections consisting essentially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious cDNA. There are provided new plasmids, pYF 5′3′ IV/G1/2 and pYFM 5.2/T3/27, which together, have the complete sequence of said YF infectious cDNA. The method for producing recombinant YF virus and the Original, Primary and Secondary Seed Lots are other embodiments of the present invention.
Claims8
A YF infectious cDNA having the base sequence set forth in SEQ ID NO:1 or functionally equivalent sequence thereof containing different codons for the same amino acid sequences.
A DNA construct comprising a vector and the genetically stable YF genome bearing the complete sequence set forth in SEQ ID NO:1 or functionally equivalent sequences thereof.
Dependencies are inferred from the claim text.