Therapeutic inhibitor of vascular smooth muscle cells
AssigneeNeoRx Corporation
InventorLawrence L. Kunz
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Abstract
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
Claims73
An intravascular stent comprising an amount of a cytoskeletal inhibitor effective to inhibit stenosis or reduce restenosis following placement of the stent.
An intravascular stent comprising an amount of a cytostatic therapeutic agent which does not exhibit substantial cytotoxicity, which agent is effective to inhibit stenosis or reduce restenosis following placement of the stent, wherein the therapeutic agent is not heparin or a radioisotope.
An intravascular stent comprising a matrix and a coating on said matrix, wherein the coating and the matrix together comprise an amount of a cytoskeletal inhibitor effective to inhibit stenosis or reduce restenosis following placement of the therapeutic stent.
An intravascular stent comprising an amount of a cytochalasin or an analog thereof effective to inhibit stenosis or reduce restenosis following placement of the therapeutic stent.
An intravascular stent comprising a cytostatic amount of an inhibitor of smooth muscle cell proliferation effective to inhibit stenosis or reduce restenosis following placement of the therapeutic stent, wherein the inhibitor is in sustained release dosage form.
Dependencies are inferred from the claim text.