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US 6,168,948 AGranted
Miniaturized genetic analysis systems and methods
AssigneeAffymetrix, Inc.
InventorsRolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
Life of this patent
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Abstract
The present invention provides a miniaturized integrated nucleic acid diagnostic device and system which includes a nucleic acid extraction zone including nucleic acid binding sites.
Claims6
A nucleic acid extraction device, comprising:
- a body having at least one chamber with at least one inlet channel;
- a porous flow-through deformable plug disposed within the chamber, the deformable plug having nucleic acid binding properties;
- and
- a flexible diaphragm for compressing said plug thereby removing trapped liquids.
1 more element
A nucleic acid extraction device, comprising:
- a body having at least one chamber with at least one inlet channel, wherein the chamber comprises a textured interior wall surface having nucleic acid binding properties;
- a porous flow-through plug disposed within the chamber, the plug having nucleic acid binding properties, and
- a piezoelectric crystal adapted to acoustically agitate a nucleic acid sample, and wherein the piezoelectric crystal is mounted to the chamber opposite the textured interior wall surface of the chamber.
A biological sample refinement device, comprising:
- a body having at least one microchamber with at least one inlet channel;
- a structure disposed within the microchamber, the structure having binding sites thereon;
- and
- a fluid distribution system for delivering a biological sample into the microchamber such that at least a portion of the sample contacts the binding sites, the fluid distribution system being adapted to deliver an adjustable volume of metered elution buffer into the microchamber.
1 more element
Dependencies are inferred from the claim text.