Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions

An oligomeric compound comprising at least one monomeric sub-unit of structure I:

• ##STR5## wherein:
• X is amino;
• R is methyl;
• L is oxygen;
• Z is O--R.sub.1 X.sub.1, where R.sub.1 is C.sub.1 -C.sub.6 alkyl, and X.sub.1 is H;
• and
• one of Q.sub.1 and Q.sub.2 is attached via a phosphorothioate linking moiety to a nucleotide, oligonucleotide, nucleoside, or oligonucleoside and the other of said Q.sub.1 and Q.sub.2, is a hydroxyl, a protected hydroxyl, an activated solid support, a nucleotide, an oligonucleotide, a nucleoside, an oligonucleoside, an oligo-nucleotide/nucleoside, an activated phosphate, a phosphate, an activated phosphite, or a phosphite;
• provided that said linking moiety is not a sulfamate group.

An oligomeric compound comprising at least one monomeric sub-unit of structure I:

• ##STR6## wherein:
• X is amino;
• R is methyl;
• L is oxygen;
• Z is O--R.sub.1 X.sub.1, where R.sub.1 is substituted C.sub.1 -C.sub.6 alkyl, and X.sub.1 is H;
• and
• one of Q.sub.1 and Q.sub.2 is attached via a phosphorothioate linking moiety to a nucleotide, oligonucleotide, nucleoside, or oligonucleoside and the other of said Q.sub.1 and Q.sub.2, is a hydroxyl, a protected hydroxyl, an activated solid support, a nucleotide, an oligonucleotide, a nucleoside, an oligonucleoside, an oligonucleotide/nucleoside, an activated phosphate, a phosphate, an activated phosphite, or a phosphite;
• provided that said linking moiety is not a sulfamate group.