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US 6,165,501 AGranted
Radiation-protective phospholipid and method
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsOren Tirosh, Ron Kohen, Jehoshua Katzhendler, Yechezkel Barenholz
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Abstract
Ether-linked phospholipids, derivatized at the polar head group with polyethylene glycol chains having molecular weights greater than 2,000 daltons, are disclosed. Lipid bilayers containing these phospholipids show high oxidative stability. Also disclosed is the use of PEG-derivatized ether-linked lipids in moisturizing and radiation-protective cosmetic compositions.
Claims10
A dialkyl ether-linked phospholipid having a phosphorus containing polar head group, as shown in formula I:
- ##STR1## wherein R.sup.1 and R.sup.2 are hydrocarbon chains contaning at least ten carbon atoms,
- PEG represents a polyethylene glycol (PEG) chain which has a molecular weight of at least 2,000 daltons,
- X is --O.sup.-, alkoxy, aminoalkoxy, or ammonium alkoxy, and
- L is a linker group connecting the polar head group of the phospholipid to the PEG chain.
1 more element
Dependencies are inferred from the claim text.