Preparation for the application of agents in mini-droplets
AssigneeIdea AG
InventorGregor Cevc
Life of this patent
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Abstract
The invention relates to a preparation for the application of agents in the form of minuscule droplets of fluid, in particular provided with membrane-like structures consisting of one or several layers of amphiphilic molecules, or an amphiphilic carrier substance, in particular for transporting the agent into and through natural barriers such as skin and similar materials. The preparation contains a concentration of edge active substances which amounts to up to 99 mol-% of the agent concentration which is required for the induction of droplet solubilization. Such preparations are suitable, for example, for the non-invasive applications of antidiabetics, in particular of insulin. The invention, moreover, relates to the methods for the preparation of such formulations.
Claims35
A method of transporting medical agents through the skin of a mammal, comprising
- (A) preparing transfersomes comprising a pharmaceutically acceptable lipid and a pharmaceutically acceptable surfactant which is compatible with said lipid, said transfersomes being contained in a pharmaceutically acceptable medium for application onto said skin, said transfersomes containing said lipid and said surfactant in a ratio which enables said transfersomes to undergo sufficient deformation to enable said transfersomes to pass through the skin of said mammal as an entity, such that the total concentration of said lipid in said medium is from about 0.1% to about 30% by weight, and the ratio of lipid to surfactant is from about 5.5:1 to about 1:500, and
- (B) applying a suitable amount of said transfersomes in said medium onto the skin of said mammal such that an effective dose of said lipid, said surfactant, or a further medical agent associated with said transfersomes is absorbed into said mammal.
Dependencies are inferred from the claim text.