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US 6,165,458 AGranted
Composition and method for dermal and transdermal administration of a cytokine
AssigneePharmaDerm Laboratories Ltd.
InventorsMarianna Foldvari, Sam Kwadwo Attah-Poku
Life of this patent
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Abstract
A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety covalently attached to the cytokine. The conjugate has enhanced cutaneous delivery relative to the cytokine alone.
Claims10
A method for dermal or transdermal administration of a cytokine, comprising
- preparing a conjugate composed of said cytokine and, covalently attached to the cytokine, at least one fatty acid moiety having between 12-24 carbon atoms, said conjugate having a substantially higher rate of skin penetration than the cytokine alone, and
- applying said conjugate to the skin of a subject in a pharmaceutically acceptable preparation.
A method of treating an infection caused by human papilloma virus in a subject, comprising
- administering topically at the site of infection, a conjugate composed of said cytokine and, covalently attached to the cytokine, at least one fatty acid moiety having between 12-24 carbon atoms, said conjugate having a substantially higher rate of skin penetration than the cytokine alone.
A method of enhancing an immune response to a vaccine, comprising
- administrating topically to a patient receiving a vaccine, a conjugate composed of a cytokine and, covalently attached to the cytokine, at least one fatty acid moiety having between 12-24 carbon atoms, said conjugate having a substantially higher rate of skin penetration than the cytokine alone.
Dependencies are inferred from the claim text.