Liquid detergents containing proteolytic enzyme and protease inhibitors
AssigneeThe Procter & Gamble Company
InventorsJohn McMillan McIver, Alan Carl Huber, Kirsten Louise McKillop
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Abstract
Aqueous liquid detergent compositions are described which comprise a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by a peptide protease inhibitor selected from the group consisting of aldehydes and trifluoromethyl ketones.
Claims21
A liquid detergent composition comprising:
- a) from about 1% to about 95% by weight of detersive surfactant;
- b) from about 0.0001% to about 5% by weight of an active proteolytic enzyme;
- and
- c) from about 0.00001% to about 5% by weight of a peptide protease inhibitor having the formula:
- Z--B--NH--CH(R)--C(O)--X
- wherein B is a peptide chain comprising from 2 to 5 amino acid moieties;
- X is hydrogen or CF.sub.3 ;
- Z is an N-capping moiety selected from the group consisting of sulfonamides, phosphonamides, thioureas, sulfenamides, sulfonic acids, phosphinamides, thiocarbamates, amidophosphates, and sulfamoyl derivatives;
- and R is selected from the group consisting of straight or branched C.sub.1 -C.sub.6 unsubstituted alkyl, phenyl, and C.sub.7 -C.sub.9 alkylaryl moieties.
The peptide compounds CH.sub.3 SO.sub.2 Phe-Gly-Ala-Leu-H, CH.sub.3 SO.sub.2 Val-Ala-Leu-H, C.sub.6 H.sub.5 CH.sub.2 O(OH)(O)P-Val-Ala-Leu-H, C.sub.6 H.sub.5 CH.sub.2 O(OH)(O)P-Val-Ala-Leu-CF.sub.3, CH.sub.3 CH.sub.2 SO.sub.2 -Phe-Gly-Ala-Leu-H, C.sub.6 H.sub.5 CH.sub.2 SO.sub.2 -Val-Ala-Leu-H, C.sub.6 H.sub.5 CH.sub.2 O(OH)(O)P-Leu-Ala-Leu-H, C.sub.6 H.sub.5 CH.sub.2 O(OH)(O)P-Phe-Ala-Leu-H, and CH.sub.3 O(OH)(O)P-Leu-Gly-Ala-Leu-H.
A liquid detergent composition comprising:
- a) from about 1% to about 95% by weight of detersive surfactant;
- b) from about 0.0001% to about 5% by weight of an active proteolytic enzyme;
- and
- c) from about 0.00001% to about 5% by weight of a peptide protease inhibitor having the formula:
- Z--B--NH--CH(R)--C(O)--CF.sub.3
- wherein B is a peptide chain comprising from 2 to 5 amino acid moieties;
- Z is an N-capping moiety selected from the group consisting of sulfonamides, phosphonamides, thioureas, sulfenamides, sulfonic acids, phosphinamides, thiocarbamates, amidophosphates, and sulfamoyl derivatives;
- and R is selected from the group consisting of straight or branched C.sub.1 -C.sub.6 unsubstituted alkyl, phenyl, and C.sub.7 -C.sub.9 alkylaryl moieties.
A liquid detergent composition comprising:
- a) from about 1% to about 95% by weight of detersive surfactant;
- b) from about 0.0001% to about 5% by weight of an active proteolytic enzyme;
- and
- c) from about 0.00001% to about 5% by weight of a peptide protease inhibitor having the formula:
- Z--B--NH--CH(R)--C(O)--X
- wherein B is a peptide chain comprising from 2 to 5 amino acid moieties;
- X is hydrogen or CF.sub.3 ;
- Z is an N-capping moiety selected from the group consisting of phosphonamides, thioureas, sulfenamides, phosphinamides, thiocarbamates, and amidophosphates;
- and R is selected from the group consisting of straight or branched C.sub.1 -C.sub.6 unsubstituted alkyl, phenyl, and C.sub.7 -C.sub.9 alkylaryl moieties.
Dependencies are inferred from the claim text.