Method for determining stimulation parameters for the treatment of epileptic seizures

A method for selecting electrical stimulation parameters to abort epileptiform activity of a human subject, the method comprising the following steps:

• (a) placing a multiplicity of brain electrodes beneath the scalp of the human subject and connecting the brain electrodes to an EEG analysis system that is adapted to display EEG signals from the electrodes;
• (b) collecting and analyzing the EEG signals from the brain electrodes with the EEG analysis system and selecting electrodes that are located in close proximity to an epileptogenic focus of the human subject;
• (c) connecting the brain electrodes to an electrical stimulator, the electrical stimulator being adapted to provide a sequence of electrical stimulation pulses that are programmable with respect to at least one of the following parameters:
• pulse amplitude, pulse frequency, pulse waveform, pulse duration, and time duration of the sequence of electrical stimulation pulses;
• (d) applying an electrical stimulation signal from the electrical stimulator to the at least two brain electrodes, which electrical stimulation signal is an evoking electrical stimulation;
• (e) adjusting the programmable parameters of the evoking stimulation and reapplying the evoking electrical stimulation until evoked epileptiform activity is seen with the EEG analysis system;
• (f) reapplying the evoking electrical stimulation that induced epileptiform activity and when the epileptiform activity is observed, then applying within a time period of less than 10 seconds a responsive electrical stimulation for aborting the epileptiform activity.