Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56.sup.lck tyrosine kinases

A compound of formula I ##STR6## wherein R.sub.1a is optionally substituted one to ten carbon atom alkyl, hydroxy, acyloxy, optionally substituted one to ten carbon atom alkoxy, optionally substituted three to seven carbon atom cyclo-alkyloxy, optionally substituted four to seven ring member oxaheterocyclyloxy, optionally substituted four to seven ring member heterocyclylcarbonyloxy or halo;

• R.sub.1b is hydrogen, optionally substituted one to ten carbon atom alkyl, hydroxy, acyloxy, optionally sutstituted one to ten carbon atom alkoxy, optionally substituted three to seven carbon atom cycloalkyloxy, optionally substituted four to seven ring member oxaheterocyclyloxy, optionally substituted four to seven ring member heterocyclylcarbonyloxy or halo;
• R.sub.1c is hydrogen, optionally substituted one to ten carbon atom alkyl, optionally substituted phenyl or naphthyl, optionally substituted five to ten ring member heteroaryl, hydroxy, acyl-oxy, optionally substituted one to ten carbon atom alkoxy, optionally substituted three to seven carbon atom cycloalkyloxy, optionally substituted four to seven ring member heterocyclyloxy, optionally substituted phenyloxy or naphthyloxy, optionally substituted five to ten ring member heteroaryloxy, optionally substituted four to seven ring member heterocyclylcarbonyloxy, halo, cyano, R.sub.5 R.sub.6 N- or acylR.sub.5 N-;
• ##STR7## R.sub.3 is hydrogen, or ortho or para fluoro, or meta lower alkyl, lower akloxy, fluoro, bromo, iodo or carbamoyl;
• R.sub.4 is hydrogen or lower alkyl;
• R.sub.5 and R.sub.6 are independently hydrogen or alkyl, or R.sub.5 or R.sub.6 taken together with the nitrogen atom to which R.sub.5 and R.sub.6 are attached form a four to seven ring member azaheterocyclyl;
• Z.sub.a is N;
• and
• Z.sub.b is NH or O, or
• an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or salt thereof, provided that R.sub.1a and R.sub.1b are not both optionally substituted alkyl.