X-ray guided drug delivery

A method of delivering an active agent to a target tissue in a vertebrate subject, the method comprising the steps of:

• (a) exposing the target tissue to ionizing radiation to target the tissue for a platelet;
• and
• (b) administering a platelet to the vertebrate subject before, after, during, or combinations thereof, exposing the target tissue to the ionizing radiation, the platelet comprising the active agent, whereby the platelet localizes in the target tissue to thereby deliver the agent to the target tissue.

A method of treating a neoplasm in a vertebrate subject, the method comprising the steps of:

• (a) exposing the neoplasm to ionizing radiation to target the neoplasm for a platelet;
• and
• (b) administering a platelet to the vertebrate subject before, after, during, or combinations thereof, exposing the neoplasm to the ionizing radiation, the platelet comprising a therapeutic agent, whereby the platelet delivers the therapeutic agent to the neoplasm to thereby treat the neoplasm.

A method of inhibiting angiogenesis in a vertebrate subject, the method comprising the steps of:

• (a) exposing a target tissue in the vertebrate subject to ionizing radiation to target the tissue for a platelet, the target tissue undergoing angiogenesis;
• and
• (b) administering a platelet to the vertebrate subject before, after, during, or combinations thereof, exposing the target tissue to the ionizing radiation, the platelet comprising an angiogenesis inhibiting amount of an angiogenesis-inhibiting therapeutic agent, whereby the platelet localizes in the target tissue to thereby inhibit angiogenesis by delivering the therapeutic agent to the target tissue.