Sliding reconstitution device with seal

A method of reconstituting a drug contained in a first container with a diluent contained in a second container, each of the containers having a closure, the method comprising the steps of:

• providing a reconstitution device having first and second ends for connecting the first and second containers, the device having a wall defining a central channel, the device further having a piercing member, wherein a portion of the piercing member is positioned within the channel, the piercing member having a central fluid passage, the first end of the device being fixedly attached to the closure of the first container and one end of the piercing member piercing the closure of the first container, the second end of the device having a receiving chamber fixedly attaching the device to the second container, the device further having first and second sleeve members capable of sliding axially with respect to one another from an inactivated position where the piercing member is outside the receiving chamber to an activated position where a portion of the piercing member is positioned inside the receiving member;
• and
• piercing the closure of the second container with an opposed end of the piercing member by moving the device from the inactivated position to the activated position to provide fluid communication through the fluid passage of the piercing member between the first container and the second container.

A method of reconstituting a drug using a diluent contained in a first container with a drug contained in a second container, each of the containers having a closure, the method comprising the steps of:

• providing a reconstitution device having first and second ends for connecting the first and second containers, the device having a wall defining a central channel, a portion of the piercing member is positioned within the channel, the piercing member having a central fluid passage, the first end of the device having a connecting member for fixedly attaching to the closure of the first container, the second end of the device having a receiving chamber fixedly attaching the device to the second container, the device further having first and second sleeve members capable of sliding axially with respect to one another from an inactivated position where the piercing member is outside the receiving chamber to an activated position where a portion of the piercing member is positioned inside the receiving chamber;
• attaching the connecting member to the first container;
• piercing the closure of the first container with an end of the piercing member;
• attaching the second end of the device to the second container;
• piercing the closure of the second container with an opposed end of the piercing member by moving the device from the inactivated position to the activated position to provide fluid communication through the fluid passage of the piercing member between the first container and the second container.

A method of reconstituting a drug using a diluent contained in a first container with a drug contained in a second container, each of the containers having a closure, the method comprising the steps of:

• providing a reconstitution device having first and second ends for connecting the first and second containers, the device having a wall defining a central channel, a portion of the piercing member is positioned within the channel, the piercing member having a central fluid passage, the first end of the device having a connecting member for connecting to the closure of the first container, the second end of the device having a receiving chamber for fixedly attaching the device to the second container, the device further having first and second sleeve members capable of sliding axially with respect to one another from an inactivated position where the piercing member is outside the receiving chamber to an activated position where a portion of the piercing member is positioned inside the receiving chamber, the device having a hermetic seal at each of the first and second ends of the device;
• removing the hermetic seal from the first end of the device;
• attaching the connecting member to the first container;
• piercing the closure of the first container with an end of the piercing member;
• removing the hermetic seal from the second end of the device;
• connecting the second container to the device with the receiving chamber;
• piercing the closure of the second container with an opposed end of the piercing member by moving the device from the inactivated position to the activated position to provide fluid communication through the fluid passage of the piercing member between the first container and the second container.