Glycoconjugates of modified camptothecin derivatives (A-or B-ring linkage)

Compounds of the formula (I) ##STR29## in which n, m and o in each case represent the number 0 or 1 and n+m+o is .gtoreq.1 where

• Cp represents a camptothecin radical of the formulae ##STR30## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently of one another may represent hydrogen, alkyl having up to 3 carbon atoms, halogen, amino, hydroxyl or nitro or
• R.sup.2 and R.sup.3 together represent a group of the formula ##STR31## p may have the values 1 or 2 and R.sup.5 represents --O--*, --NH* or ##STR32## or represents --*NR.sup.6, in which R.sup.6 represents arylmethyl or hetarylmethyl, ##STR33## in which R.sup.7 and R.sup.8 are as defined for R.sup.2 and R.sup.3 and may be identical or different to these, ##STR34## in which R.sup.9 represents hydrogen or --CH.sub.2 --N(CH.sub.3).sub.2 and
• R.sup.10 represents hydrogen or ethyl, ##STR35## in which R.sup.11 and R.sup.12 are as defined for R.sup.2 and R.sup.3 and may be identical or different to these, or ##STR36## in which R.sup.13 and R.sup.14 are as defined for R.sup.2 and R.sup.3 and may be identical or different to these,
• where Cp is attached to M via the bonds labelled *,
• M represents a bridge grouping whose main chain includes up to 21 atoms in linear order,
• L.sup.1, L.sup.2 and L.sup.3 independently of one another each represent linker groupings,
• Sp.sup.1, Sp.sup.2 and Sp.sup.3 independently of one another each represent arylene having up to 10 carbon atoms or represent alkylene having up to 8 carbon atoms which are in each case optionally substituted, and
• K.sup.1, K.sup.2 and K.sup.3 independently of one another each represent a radical of the formula (II) ##STR37## in which A represents methyl, hydroxymethyl, alkoxymethyl having up to 6 carbon atoms, acyloxymethyl having up to 6 carbon atoms or a radical of the formula --CH.sub.2 --B in which
• B represents a radical of the formula (II),
• R.sup.15, R.sup.16 and R.sup.17 independently of one another each represent hydrogen, hydroxyl, optionally hydroxyl-substituted alkoxy having up to 6 carbon atoms, amino which is optionally substituted by alkyl or acyl having up to 6 carbon atoms, halogen, sulphate or a group of the formula ##STR38## in which R.sup.18 and R.sup.19 independently of one another each represent hydroxyl or alkoxy having up to 6 carbon atoms or represent amino which is optionally substituted by alkyl having up to 6 carbon atoms, and
• s and t independently of one another may each have the values 0, 1, 2, 3 or 4, or
• R.sup.15, R.sup.16 and R.sup.17 independently of one another each represent a radical of the formula (II) or
• two of the radicals R.sup.15, R.sup.16, R.sup.17 together represent an epoxy group,
• and their isomers, isomer mixtures and salts.