US 6,154,706 A · Apparatus and method for kinetic analysis of the intraoperative assay for parathyroid hormone

Abstract

An apparatus for predicting a residual hormone concentration in a patient after a removal of a portion of the patient's glandular tissue which secretes the hormone, includes an input device constructed to receive a plurality of measured hormone concentrations corresponding to a plurality of human fluid samples taken from a patient at a plurality of sample times, respectively; and further includes a computer processor configured to iteratively calculate a residual hormone concentration. In accordance with one feature of the present invention, the computer processor is configured to generate data denoting a residual amount of glandular tissue that will remain in the patient after the removal of the portion of the patient's glandular tissue; and the apparatus further comprises an output device constructed to output the generated data denoting the residual amount of glandular tissue. The computer processor is further configured to iteratively calculate a half-life value of the hormone concentration in the patient.

Claims78

Dependent claims

A method of using a computer processor to predict a residual hormone concentration in a patient after a removal of a portion of the patient's tissue which secretes the hormone, the method comprising the following steps:

(a) providing first, second and third measured hormone concentrations corresponding to first, second and third animal fluid samples taken from a patient at first, second and third sample times, respectively;
(b) assigning an estimated value to the residual hormone concentration of the patient that is to be predicted;
(c) determining an expression in half lifes of the second sample time, using the estimated value of step (b);
(d) determining an expression in half lifes of the third sample time, using the determined expression in half lifes of the second sample time of step (c) and a ratio of the third sample time and the second sample time;
(e) determining a hormone concentration that would remain at the second sample time if the residual hormone concentration were zero, using the determined expression in half lifes of the second sample time;
(f) calculating a difference between the determined hormone concentration and the third measured hormone concentration;
(g) remembering the estimated value for the residual hormone concentration as an old estimated value;
(h) finding a new estimated value for the residual hormone concentration, using the calculated difference of step (f);
(i) repeating steps (c) through (g) until a difference or percent change between the old estimated value and the new estimated value reaches a predetermined value;
and
(j) outputting the new estimated value of step (I) as the predicted residual hormone concentration.

8 more elements

A method of using a computer processor to predict a residual amount of tissue remaining in a patient after a removal of a portion of the tissue, the tissue when in the patient secreting a hormone, the method comprising the following steps:

(a) providing first, second and third measured hormone concentrations corresponding to first, second and third animal fluid samples taken from a patient at first, second and third sample times, respectively;
(b) assigning an estimated value to a residual hormone concentration of the patient that is to be predicted;
(c) determining an expression in half lifes of the second sample time, using the estimated value of step (b);
(d) determining an expression in half lifes of the third sample time, using the determined expression in half lifes of the second sample time of step (c) and a ratio of the of the third sample time and the second sample time;
(e) determining a hormone concentration that would remain at the third sample time if the residual hormone concentration were zero, using the determined expression in half lifes of the third sample time;
(f) calculating a difference between the determined hormone concentration and the third measured hormone concentration;
(g) remembering the estimated value for the residual hormone concentration as an old estimated value;
(h) finding a new estimated value for the residual hormone concentration, using the calculated difference of step (f);
(i) repeat steps (c) through (h) until a difference or percent change between the old estimated value and the new estimated value reaches a predetermined value;
and
(j) outputting data that represents a residual amount of tissue that remains in the patient after the removal of the portion of the tissue.

8 more elements

(a) providing first, second and third measured hormone concentrations corresponding to first, second and third animal fluid samples taken from a patient at first, second and third sample times, respectively;
(b) assigning an estimated value to the residual hormone concentration of the patient that is to be predicted;
(c) determining an expression in half lifes of the second sample time, using the estimated value of step (b);
(d) determining a hormone concentration that would remain at the second sample time if the residual hormone concentration were zero, using the determined expression in half lifes of the second sample time of step (c);
(e) calculating a difference between the determined hormone concentration and the third measured hormone concentration;
(f) remembering the estimated value for the residual hormone concentration as an old estimated value;
(g) finding a new estimated value for the residual hormone concentration, using the calculated difference of step (e);
and
(h) repeating steps (c) through (g) until a difference or percent change between the old estimated value and the new estimated value reaches a predetermined value.

6 more elements

Dependencies are inferred from the claim text.

Apparatus and method for kinetic analysis of the intraoperative assay for parathyroid hormone

Life of this patent

Apparatus and method for kinetic analysis of the intraoperative assay for parathyroid hormone

Life of this patent

Abstract

Claims78