Compositions comprising polyquaterniums in combination with polymeric biguanides for disinfecting contact lenses
OwnerDavid J. McCanna, Stephen E. Maier +3inventors
InventorsDavid J. McCanna, Stephen E. Maier, David J. Heiler, Susan P. Spooner, Erning Xia
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Abstract
The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising the combination of a polymeric biguanide and a polyquaternium polymer of a substituted or unsubstituted vinylimidazole or its vinylimidazoliuum salt, which copolymer has a weight average molecular weight of 5,000 to 5,000,000. The invention is also directed to an improved method of disinfecting a contact lens.
Claims23
An ophthalmically safe solution for treating contact lenses comprising an aqueous solution comprising, before mixing, the following components:
- (a) between about 10 and 400 ppm of a polyquaternium polymer comprising 10 to 45 mole percent of a quaternary-amine-functional repeat unit that is the copolymerization reaction product of one or more comonomers selected from the group consisting of substituted or unsubstituted vinylimidazoles or their vinylimidazoliuum salts, and mixtures thereof, which polymer has a weight average molecular weight of 5,000 to 5,000,000;
- and
- (b) a polymeric biguanide, in the total amount of between about 0.10 to about 3.0 ppm, having the formula:
- ##STR6## wherein Z is an organic divalent bridging group which may be the same or different throughout the polymer, n is on average at least 3, and X.sup.1 and X.sup.2 are independently selected from the groups ##STR7## (c) an effective amount of a buffering agent to buffer said composition;
- and
- (d) water in an amount of at least 80% by weight.
A method of treating a soft contact lens with a solution, which method comprises:
- (a) soaking the lens in a solution, such that acceptable disinfection of the contact lens is obtained with the solution, the solution comprising, in formulation, the following components:
- (i) a polyquaternium polymer, in the total amount of between about 10 and 400 ppm, which polyquaternium polymer comprises 10 to 45 mole percent of a quaternary-amine-functional repeat unit that is the copolymerization reaction product of one or more comonomers selected from the group consisting of substituted or unsubstituted vinylimidazoles or their vinylimidazoliuum salts and mixtures thereof, and which polymer has a weight average molecular weight of 5,000 to 5,000,000;
- (ii) a polymeric biguanide, in the total amount of between about 0.10 to about 3.0 ppm, having the following general formula:
- ##STR9## wherein Z is an organic divalent bridging group which may be the same or different throughout the polymer, n is on average at least 3, and X.sup.1 and X.sup.2 are independently selected from the groups ##STR10## (iii) an effective amount of a buffering agent to buffer said composition;
- and
- (b) directly placing the treated lens on the eye of the wearer, wherein (i) rinsing with a different solution prior to replacement on the eye is not required, and (ii) no other solution is required for daily disinfection of the lens.
Dependencies are inferred from the claim text.