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US 6,153,189 AGranted
Human TRK receptors and neurotrophic factor inhibitors
AssigneeGenentech, Inc.
InventorsLeonard G. Presta, David L. Shelton, Roman Ufer
Life of this patent
Estimating the term…
Abstract
The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
Claims8
A method of inhibiting a biological activity of a neurotrophin comprising contacting said neurotrophin with a chimeric polypeptide comprising an immunoglobulin constant domain sequence fused to a polypeptide sequence comprising a second immunoglobulin-like domain sequence of human trkA, human trkb, or human trk C, wherein said chimeric polypeptide binds said neurotrophin.
Dependencies are inferred from the claim text.