Human antibodies derived from immunized xenomice
AssigneeAbgenix, Inc.
InventorsRaju Kucherlapati, Aya Jakobovits, Daniel G. Brenner, Daniel J. Capon, Sue Klapholz
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Abstract
Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
Claims12
A transgenic mouse wherein all of the somatic and germ cells comprise a DNA fragment of human chromosome 14 from the five most proximal V.sub.H gene segments, continuing through the D segment genes, the J segment genes and the constant region genes through C.delta. of the human immunoglobulin heavy chain locus, wherein said fragment does not contain a C.gamma. gene, and wherein said fragment is operably linked to a human C.gamma.2 region gene;
- said transgenic mouse producing fully human IgG2 heavy chains specific for a desired antigen when immunized with said desired antigen.
The yHlC YAC having ATCC accession number 74367.
Dependencies are inferred from the claim text.