4,10-.beta.-diacetoxy- 2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-9-oxo-19-norcyclopropa[g]t ax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate and its process of preparation
AssigneeAventis Pharma S.A.
InventorsEric Didier, Michel Lavigne, Jean-Rene Authelin
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Abstract
The present invention is directed to 4,10.beta.-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-9-oxo- 19-norcyclopropa(g)tax-11-en-13.alpha.-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate and a process for its preparation.
Claims6
4,10.beta.-diace toxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-9-oxo-19-norcyclopropa( g)tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate.
A process for the preparation of 4,10.beta.-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-9-oxo- 19-norcyclopropa(g)tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate;
- wherein 4,10.beta.-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-9-oxo- 19-norcyclopropa(g)tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate or its hydrate is crystallized from a mixture of water and an aliphatic alcohol containing 1 to 3 carbon atoms or from a mixture of water and a ketone containing 3 to 4 carbon atoms;
- and
- further wherein the product obtained is dried under reduced pressure or is dried and optionally maintained under relative humidity conditions greater than or equal to 40%.
Dependencies are inferred from the claim text.