N-aryloxyethyl-indoly-alkylamines for the treatment of depression
AssigneeAmerican Home Products Corporation
InventorsRichard E. Mewshaw, James A. Nelson
Life of this patent
Estimating the term…
Abstract
Compounds effective in treating disorders of the serotonin-affected neurological systems are provided, such compounds having the following formula: ##STR1## wherein: R.sub.1 is hydrogen, lower alkyl, phenyl, or substituted phenyl; X and Y together complete a lactam, imidazole, imidazolone, or thioimidazolone ring; Z is hydrogen, halogen, or lower alkoxy; W is hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or a trifluoromethyl group; and n=2 to 5; or pharmaceutically acceptable salts thereof.
Claims10
A compound of the formula:
- ##STR7## wherein:
- R.sub.1 is hydrogen, lower alkyl, phenyl, or substituted phenyl;
- X and Y together complete a lactam, iridazole, imidazolone, or thioimidazolone ring;
- Z is hydrogen, halogen, or lower alkoxy;
- W is hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or a trifluoromethyl group;
- and n=2 to 5;
- or pharmaceutically acceptable salts thereof.
A pharmaceutical composition comprising a compound of the formula:
- ##STR8## wherein:
- R.sub.1 is hydrogen, lower alkyl, phenyl, or substituted phenyl;
- X and Y togethier complete a lactam, imidazole, imidazolone, or thioimdidazolone ring;
- Z is hydrogen, halogen, or lower alkoxy;
- W is hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or a trifluoromethyl group;
- and n=2 to 5;
- or pharmaceutically acceptable salts thereof.
A method for alleviating the symptoms of depression in a patient in need thereof comprising administering to said patient an antidepressant effective amount of a compound of the formula:
- ##STR9## wherein:
- R.sub.1 is hydrogen, lower alkyl, phenyl, or substituted phenyl;
- X and Y together complete a lactam, imidazole, imidazolone, or thioimidazolone ring;
- Z is hydrogen, halogen, or lower alkoxy;
- W is hydrogen, halogen, lower alkoxy, lower alkyl, cyano, or a trifluoromethyl group;
- and n=2 to 5;
- or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.