Method for producing 5-aminomethyl-2-chloropyridines
AssigneeBayer Aktiengesellschaft
InventorsReinhard Lantzsch, Uwe Stelzer
Life of this patent
Estimating the term…
Abstract
The present invention relates to the preparation of 5-aminomethyl-2-chloropyridines by reacting a mixture of 5-chloromethyl-2-chloropyridine and 5-dichloromethyl-2-chloropyridine with substituted amines. The mixture of 5-chloromethyl-2-chloropyridine and 5-dichloromethyl-2-chloropyridine is obtained by chlorination of 5-methyl-2-chloropyridine.
Claims1
A process for the preparation of a 5-aminomethyl-2-chloropyridines of the formula (I) ##STR6## wherein R is hydrogen or optionally substituted C.sub.1 -C.sub.4 -alkyl, comprising chlorinating in a first stage, 5-methyl-2-chloropyridine in the form of its salt using inorganic acids optionally in the presence of a diluent at temperatures between 50 and 150.degree. C., in the presence of a free-radical former until the content of 5-methyl-2-chloropyridine is <about 3%, and then, optionally after the diluent has been removed, in a second stage reacting, the resulting reaction mixture with amine of the formula (II)
- R--NH.sub.2 (II)
- wherein
- R is hydrogen or optionally substituted C.sub.1 -C.sub.4 -alkyl under reducing conditions.
Dependencies are inferred from the claim text.