Morphine derivatives with analgesic activity

A morphinan derivative of the formula ##STR6## wherein D denotes a straight-chained or branched, optionally halogenated C.sub.1-4 -alkyl group,

• the dotted line represent a chemical bond indicating that the compound is a morphine or 7,8-dihydromorphine derivative,
• P denotes a group --C(L) (R.sub.1) (R.sub.2),
• L denotes a group --A.sub.1 --(C(R.sub.3) (R.sub.4)).sub.k --A.sub.2 --B
• k is an integer from 0 to 5;
• R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another denote hydrogen, a straight-chained or branched, C.sub.1-4 -alkyl group, a C.sub.2-4 -alkenyl group, or a group --(CH.sub.2).sub.x --OR.sub.7, --(CH.sub.2).sub.x --OC(O)R.sub.7, (CH.sub.2).sub.x --F, (CH.sub.2).sub.x --Cl, (CHF).sub.x --F, (CHCl).sub.x --Cl, (CF.sub.2).sub.x --F, (CCl.sub.2).sub.x --Cl,
• x is an integer from 0 to 2,
• A.sub.1 and A.sub.2 independently of each other denote a group --(CH.sub.2).sub.m --,
• m is an integer from 0 to 4,
• B is a hydrogen atom or a group X, and
• X denotes a group --(CH.sub.2).sub.n --OH, --(CH.sub.2).sub.n --CO.sub.2 R.sub.7, --(CH.sub.2).sub.n --CN, --(CH.sub.2).sub.n --CONR.sub.5 OR.sub.6, --(CH.sub.2).sub.n CONR.sub.5 R.sub.6, --(CH.sub.2).sub.n --OR.sub.5, --(CH.sub.2).sub.n --COR.sub.5, --(CH.sub.2).sub.n --OC(O)R.sub.7, --(CH.sub.2).sub.n --CONR.sub.5 OR.sub.6, --(CH.sub.2 O.sub.n --NR.sub.5 C(O)R.sub.6, --(CH.sub.2).sub.n --SR.sub.5, --(CH.sub.2).sub.n S(O)R.sub.5, --(CH.sub.2).sub.n --S(O).sub.2 NR.sub.5 R.sub.6, --(CH.sub.2).sub.n --NR.sub.5 R.sub.6, --(CH.sub.2).sub.n --NHC(O)R.sub.5, --(CH.sub.2).sub.n --NHS(O).sub.2 R.sub.5, --(CH.sub.2).sub.n --F, --(CH.sub.2).sub.n --Cl, --(CH.sub.2).sub.n --Br, --(CH.sub.2).sub.n --NO.sub.2
• n is an integer from 0 to 4,
• R.sub.5, R.sub.6 and R.sub.7 independently of one another denote hydrogen or a straight-chained or branched C.sub.1-4 -alkyl group, a C.sub.2-4 -alkenyl group or an aryl or benzyl group, or a pharmaceutically acceptable salt thereof.