Polyketide synthase enzymes and recombinant DNA constructs therefor
AssigneeKosan Biosciences, Inc.
InventorKai Wu
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Abstract
Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the neuroimmunophilin FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application in agriculture, medicine, and animal health.
Claims5
An isolated nucleic acid that comprises a coding sequence for a polyketide synthase enzyme identical to or isolated from a polyketide synthase enzyme coding sequence contained within a cosmid selected from the group consisting of cosmids 34-183, 34-122, and 34-126.
Dependencies are inferred from the claim text.