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US 6,150,501 AGranted
Tyrosine-containing cyclophilin and related methods
AssigneeNew England Biolabs, Inc.
InventorsClotilde K. S. Carlow, Xiqiang Hong, Dong Ma
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Abstract
The present invention relates to the use of these cyclophilins, hereinafter referred to as `tyrosine-containing` cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.
Claims5
An isolated and purified cyclophilin endogenous to the parasites Onchocerca volvulus, Brugia malayi, and Dirofilaria immitis, wherein said cyclophilin includes a tyrosine residue in the drug-binding site.
Dependencies are inferred from the claim text.