Carriers targettable to organ
AssigneesHisamitsu Pharmaceutical Co., Inc., Rohto Pharmaceutical Co., Ltd.
InventorsYoshiyuki Takei, Atsushi Maruyama, Toshihiro Akaike, Sunao Kawano, Shigetoshi Okumura, Masayuki Nogawa, Shoichiro Asayama
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Abstract
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a part capable of binding to the foreign substance electrostatically, and contains one or more monomer unit having side chain with amino or imino group capable of coupling to hyarulonic acid, which is useful for delivering a foreign substance to a target organ, especially liver.
Claims16
A carrier for delivering a foreign substance to a target organ having receptors for hyaluronic acid which comprises a graft copolymer comprising (1) a polymer main chain which has a region capable of binding to the foreign substance electrostatically and has one or more monomer units having a side chain with an amino or an imino group capable of coupling to hyaluronic acid and (2) hyaluronic acid grafted to the polymer main chain;
- said polymer main chain comprising amino acids or amino acid derivatives coupled through peptide bonds.
A graft copolymer comprising (1) a polymer main chain which has a region capable of binding to a foreign substance electrostatically and has one or more monomer units having a side chain with an amino or an imino group capable of coupling to hyaluronic acid and (2) hyaluronic acid grafted to the polymer main chain;
- said polymer main chain comprises amino acids or amino acid derivatives coupled through peptide bonds.
Dependencies are inferred from the claim text.