Treatment of estrogen-receptor positive breast cancer and estrogen-receptor negative breast cancer with retinoid with CH.sub.2 OH at the side chain terminal position
AssigneeCornell Research Foundation, Inc.
InventorsLorraine Gudas, Fadila Derguini
Life of this patent
Estimating the term…
Abstract
Certain retinoids with CH.sub.2 OH at the side chain terminal position, preferably 4-oxoretinol, inhibit growth of estrogen-receptor positive and estrogen-receptor negative breast cancer tumor cell lines and have utility for adjuvant therapy and treatment of metastatic disease.
Claims14
A method of treating estrogen-receptor positive breast cancer in a patient afflicted with this condition, comprising administering to said patient as adjuvant therapy a therapeutically effective amount of a retinoid having the structure ##STR4## wherein the configuration at the 7-, 9-, 11- and 13-position double bonds is independently Z or E and wherein R.sub.1 is selected from the group consisting of ##STR5## wherein the keto group at the 4-position is free or protected;
- and ##STR6## wherein X is selected from the group consisting of hydrogen and C.sub.1-6 -alkyl and wherein Y is selected from the group consisting of hydroxy and C.sub.1-6 -alkoxyl, and wherein the absolute configuration at the 4-position is independently R or S, or a mixture of R and S.
A method of treating estrogen-receptor negative breast cancer in a patient affected with this condition comprising administering to said patient as adjuvant therapy a therapeutically effective amount of 4-oxoretinol.
A method of treating estrogen-receptor positive breast cancer that has metastasized in a patient affected with this condition, comprising administering to said patient a therapeutically effective amount of a retinoid having the structure ##STR7## wherein the configuration at the 7-, 9-, 11- and 13-position double bonds is independently Z or E and wherein R.sub.1 is selected from the group consisting of ##STR8## wherein the keto group at the 4-position is free or protected;
- and ##STR9## wherein X is selected from the group consisting of hydrogen and C.sub.1-6 -alkyl and wherein Y is selected from the group consisting of hydroxy and C.sub.1-6 -alkoxyl, and wherein the absolute configuration at the 4-position is independently R or S, or a mixture of R and S.
A method of treating estrogen-receptor negative breast cancer that has metastasized in a patient affected with this condition, comprising administering to said patient a therapeutically effective amount of 4-oxoretinol.
Dependencies are inferred from the claim text.