Use of MEK1 inhibitors as protective agents against damage due to ischemia
AssigneeThe General Hospital Corporation
InventorsAlessandro Alessandrini, Joseph Bonventre, Michael A. Moskowitz, Shobu Namura
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Abstract
The invention relates to the use of MEK1 inhibitors to reduce tissue damage resulting from ischemia and/or reperfusion, particularly brain damage associated with ischemia resulting from stroke. Pharmaceutical compositions, kits and perfusion fluids including MEK1 inhibitors are also provided.
Claims11
A method for treating a subject having a condition characterized by ischemia comprising
- administering to a subject in need of such treatment a MEK1 inhibitor in an amount effective to reduce MEK1 activity, wherein the subject is free of symptoms otherwise calling for treatment with the MEK1 inhibitor.
A pharmaceutical composition comprising
- a MEK1 inhibitor, and
- a non-MEK1 inhibitor anti-stroke agent, together in an amount effective for treating an ischemic condition.
A kit comprising a package housing
- a first container containing a MEK1 inhibitor, and
- instructions for using the MEK1 inhibitor in the treatment of an ischemic condition.
A medical product comprising
- an isolated organ in a perfusion fluid containing a MEK1 inhibitor.
A medical product comprising an organ perfusion fluid containing a MEK1 inhibitor.
Dependencies are inferred from the claim text.