5-aroylnaphthalene derivatives as anti-inflammatory agents

A compound selected from the group of compounds represented by formula (I):

• ##STR21## wherein:
• A is a bond, --CH.sub.2 --, --CH(OH)--, --C.dbd.NOR.sup.4 --, --C(O)--, --NR.sup.5 --, --O--, or --S(O).sub.n -- where n is an integer from 0 to 2, R.sup.4 is hydrogen or akyl, and R.sup.5 is hydrogen, alkyl, or acyl;
• Z is a group represented by formula (C) or (D):
• ##STR22## where:
• X is O or S;
• R.sup.8 is hydrogen, alkyl, haloalkyl, alkoxy, cycloalkyloxy, haloalkyloxy, alkylthio, cycloalkylthio, nitro, cyano, hydroxy, or halo;
• R.sup.1 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkenyloxy, cycloalkyloxy, cycloalkylalkyloxy, haloalkyloxy, hydroxyalkyloxy, alkoxyalkyloxy, alkylthio, cycloalkylthio, cycloalkylalkylthio, hydroxy, halo, cyano, carboxy, alkoxycarbonyl, acyl, --C.dbd.NOR.sup.4, --NR.sup.9 R.sup.10, --CONR.sup.9 R.sup.10, --OCONR.sup.9 R.sup.10, or --OSO.sub.2 R.sup.11 where R.sup.4 is as defined previously;
• R.sup.9 and R.sup.10 are independently hydrogen, alkyl, or acyl;
• and R.sup.11 is alkyl, cycloalkyl, or haloalkyl;
• R.sup.2 is hydrogen, alkyl, alkoxy, halo, nitro, or --NR.sup.9 R.sup.10 ;
• and
• R.sup.3 is --SO.sub.2 R.sup.12 or --SO.sub.2 NR.sup.13 R.sup.14 where:
• R.sup.12 is alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, or alkoxycarbonylalkyl;
• R.sup.13 is hydrogen, alkyl, or acyl;
• and
• R.sup.14 is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, aralkyl, heteroaralkyl, heterocyclo, heterocycloalkyl, acyl, hydroxy, or alkoxy;
• or R.sup.13 and R.sup.14 together with the nitrogen atom to which they are attached form a heterocycloamino group;
• and
• their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers.