Pharmaceutical composition
AssigneeTakeda Chemical Industries, Ltd.
InventorsHitoshi Ikeda, Takashi Sohda, Hiroyuki Odaka
Life of this patent
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Abstract
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.
Claims18
A method for treating lipid metabolism disorders in a mammal in need thereof, which comprises administering to such mammal a therapeutically effective amount of a compound represented by the formula:
- ##STR8## wherein R' represents an optionally substituted hydrocarbon or heterocyclic group;
- Y represents a group represented by --CO--, --CH(OH)-- or --NR.sup.3 -- wherein R.sup.3 represents an optionally substituted alkyl group;
- m is 0 or 1;
- n is 0, 1 or 2;
- X represents CH or N;
- A represents a bond or a C.sub.1-7 divalent aliphatic hydrocarbon group;
- Q represents oxygen atom or sulfur atom;
- R.sup.1 represents hydrogen atom or an alkyl group;
- ring E may optionally have 1 to 4 further substituents, and the substituents may optionally be combined with R.sup.1 to form a ring;
- L and M respectively represent hydrogen atom, or L and M may optionally be combined with each other to form a bond;
- with a proviso that R' does not represent benzopyranyl group when m and n are O, X represents CH, A represents a bond, Q represents sulfur atom, R.sup.1, L and M represent hydrogen atoms and ring E does not have further substituents;
- or a pharmacologically acceptable salt thereof, in combination with an insulin secretion enhancer.
A method for treating glycometabolism disorders in a mammal in need thereof, which comprises administering to such mammal a therapeutically effective amount of a compound represented by the formula:
- wherein R' represents an optionally substituted hydrocarbon or heterocyclic group;
- Y represents a group represented by --CO--, --CH(OH)-- or --NR.sup.3 -- wherein R.sup.3 represents an optionally substituted alkyl group;
- m is 0 or 1;
- n is 0, 1 or 2;
- X represents CH or N;
- A represents a bond or a C.sub.1-7 divalent aliphatic hydrocarbon group;
- Q represents oxygen atom or sulfur atom;
- R.sup.1 represents hydrogen atom or an alkyl group;
- ring E may optionally have 1 to 4 further substituents, and the substituents may optionally be combined with R.sup.1 to form a ring;
- L and M respectively represent hydrogen atom, or L and M may optionally be combined with each other to form a bond;
- with a proviso that R' does not represent benzopyranyl group when m and n are O, X represents CH, A represents a bond, Q represents sulfur atom, R.sup.1, L and M represent hydrogen atoms and ring E does not have further substituents;
- or a pharmacologically acceptable salt thereof, in combination with an insulin secretion enhancer.
Dependencies are inferred from the claim text.