Bicyclic nitrogen heterocycles

A bicyclic heterocycle, comprising a compound of the formula ##STR9## wherein R.sup.1 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl,

• R.sup.2 is lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, and
• R.sup.3 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl, lower cycloalkenyl or lower cycloalkyl-lower alkyl,
• wherein each said aryl and heteroaryl is independently unsubstituted or substituted by one or more groups selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower-alkoxy lower alkyl, trifluoromethyl, hydroxy, hydroxy lower-alkyl, carboxylic acid, carboxylic ester, nitro, amino, phenyl, --Z--NR.sup.4 R.sup.5 and --Z--OR.sup.6 ;
• wherein Z is --O(CH.sub.2).sub.n -- in which n is 2, 3 or 4, or --(CH.sub.2).sub.m -- in which m is 1, 2, 3 or 4 and wherein each hydrogen of the --(CH.sub.2).sub.m chain is present or independently replaced by lower-alkyl, hydroxy lower-alkyl or lower-alkyloxy lower-alkyl;
• and
• R.sup.4 and R.sup.5 are each individually hydrogen or lower alkyl or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached are a 4-, 5- or 6-membered saturated or partially unsaturated or 5- or 6-membered aromatic heterocyclic group which contains one or more hetero atoms selected from nitrogen, sulfur and oxygen and which is optionally substituted by lower alkyl, lower alkoxy and/or oxo and/or which is optionally benz-fused;
• and
• R.sup.6 is hydrogen or lower-alkyl;
• or, if the compound is basic a pharmaceutically acceptable salt thereof with an acid, and if the compound is acidic a pharmaceutically acceptable salt thereof with a base.