1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes and their use in medical treatments
AssigneeCouncil of Scientific and Industrial Research
InventorsNeelima Sinha, Sanjay Jain, Anil Kumar Saxena, Nitya Anand, Ram Mohan Saxena, Mangal Prasad Dubey, Madhur Ray, Gyanendra K. Patnaik, deceased
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Abstract
A chemical compound and composition of Formula 1: ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; said compounds and compositions as being useful therapeutic agents for hypertension, ischemic, cardiovascular and other adrenergic receptor related disorders.
Claims12
A propane compound of 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin-1-yl ]propane or 1-[4-arylpiperazin-1-yl]-3-[2-oxopiperidin-1-yl ]propane having formula I:
- ##STR5## wherein Ar represents pyridyl, or a phenyl ring substituted with trifluoromethyl halogen, alkoxy, or alkyl, and n is 1 or 2.
A pharmaceutical composition comprising a compound of formula I:
- ##STR6## wherein Ar represents a phenyl ring substituted with trifluoromethyl, halogen, alkoxy, or alkyl groups, or Ar represents a pyridyl ring, and n is 1 or n is 2.
Dependencies are inferred from the claim text.